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Article

Identification of conformational core epitope Lys⁶⁸ in C5a based on the 3-D modeling complex C5a and its functional antibody F20.

Molecular immunology - 1 Jul 2011

Wei Huawei, Lin Zhou, Feng Jiannan, Peng Hui, Guo Renfeng, Han Gencheng, Geng Shusheng, Lang Xiaoling, Sun Yingxun, Shen Beifen, Li Yan

Abstract excerpt

Inhibition of C5a by antibodies has been demonstrated to dramatically improve survival in various sepsis models in mice and rats. The structural basis of C5a mediated bioactivity and C5a antibody mediated neutralization are of interesting to be investigated. In the previous study, we obtained a novel functional mouse antibody named as F20. With computer-guided modeling method, the 3-D theoretical structure of F20...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21529950
DOI: 10.1016/j.molimm.2011.03.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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