Article
Prediction of binding characteristics between von Willebrand factor and platelet glycoprotein Ibα with various mutations by molecular dynamic simulation.
Thrombosis research - 1 Dec 2019
Goto Shinichi, Oka Hideki, Ayabe Kengo, Yabushita Hiroto, Nakayama Masamitsu, Hasebe Terumitsu, Yokota Hideo, Takagi Shu, Sano Motoaki, Tomita Aiko, Goto Shinya
Abstract excerpt
INTRODUCTION: Binding of platelet glycoprotein (GP)Ibα with von-Willebrand factor (VWF) exclusively mediates the initial platelet adhesion to injured vessel wall. To understand the mechanism of biomedical functions, we calculated the dynamic fluctuating three-dimensional (3D) structures and dissociation energy for GPIbα with various single amino-acid substitution at G233, which location is known to cause...
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