Article

Structural basis of a high-affinity antibody binding to glycoprotein region with consecutive glycosylation sites

2022-07-24

Abstract excerpt

Consecutive glycosylation sites occur in both self and viral proteins. Glycan-shielding of underneath peptide region is a double-edged sword, that avoids immune attack to self-proteins, but helps viruses including HIV-1 and SARS-CoV2 to escape antibody binding. Here we report a high-affinity antibody, 16A, binding to linear peptide containing consecutive glycosylation sites. Co-crystallization of 16A Fab and glyco...

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Identifiers and source

Literature Corpus work: 887a7f7b-e85e-5a3e-a2e1-d67b73d56af5
DOI: 10.1101/2022.07.24.501275

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