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Article

Paratope determination of the antithrombotic antibody 82D6A3 based on the crystal structure of its complex with the von Willebrand factor A3-domain.

The Journal of biological chemistry - 27 Jan 2006

Staelens Stephanie, Hadders Michael A, Vauterin Stephan, Platteau Céline, De Maeyer Marc, Vanhoorelbeke Karen, Huizinga Eric G, Deckmyn Hans

Abstract excerpt

The antithrombotic monoclonal antibody 82D6A3 is directed against amino acids Arg-963, Pro-981, Asp-1009, Arg-1016, Ser-1020, Met-1022, and His-1023 of the von Willebrand factor A3-domain (Vanhoorelbeke, K., Depraetere, H., Romijn, R. A., Huizinga, E., De Maeyer, M., and Deckmyn, H. (2003) J. Biol. Chem. 278, 37815-37821). By this, it potently inhibits the interaction of von Willebrand factor to collagens, which...

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Identifiers

PMID: 16314412
DOI: 10.1074/jbc.M508191200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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