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Article

Selective blockade of glycoprotein VI clustering on collagen helices.

The Journal of biological chemistry - 3 Nov 2006

O'Connor Marie N, Smethurst Peter A, Davies Lorna W, Joutsi-Korhonen Lotta, Onley David J, Herr Andrew B, Farndale Richard W, Ouwehand Willem H

Abstract excerpt

Platelet activation by collagen relies on the interaction of the receptor glycoprotein VI (GPVI) with collagen helices. We have previously generated two recombinant single chain human antibodies (scFvs) to human GPVI. The first, 10B12, binds to the collagen-binding site on the apical surface between the two immunoglobulin-like domains (D1D2) of the receptor and so directly inhibits GPVI function. The second, 1C3,...

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Identifiers

PMID: 16956881
DOI: 10.1074/jbc.M606480200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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