Article
Genetic polymorphisms and their association with brain and behavioural measures in heterogeneous stock mice.
Scientific reports - 1 Feb 2017
Janecka Magdalena, Marzi Sarah J, Parsons Michael J, Liu Lin, Paya-Cano Jose L, Smith Rebecca G, Fernandes Cathy, Schalkwyk Leonard C
Abstract excerpt
Although the search for quantitative trait loci for behaviour remains a considerable challenge, the complicated genetic architecture of quantitative traits is beginning to be understood. The current project utilised heterogeneous stock (HS) male mice (n = 580) to investigate the genetic basis for brain weights, activity, anxiety and cognitive phenotypes. We identified 126 single nucleotide polymorphisms (SNPs) in...
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