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Article

Reciprocal Effects on Neurocognitive and Metabolic Phenotypes in Mouse Models of 16p11.2 Deletion and Duplication Syndromes.

PLoS genetics - 1 Feb 2016

Arbogast Thomas, Ouagazzal Abdel-Mouttalib, Chevalier Claire, Kopanitsa Maksym, Afinowi Nurudeen, Migliavacca Eugenia, Cowling Belinda S, Birling Marie-Christine, Champy Marie-France, Reymond Alexandre, Herault Yann

Abstract excerpt

The 16p11.2 600 kb BP4-BP5 deletion and duplication syndromes have been associated with developmental delay; autism spectrum disorders; and reciprocal effects on the body mass index, head circumference and brain volumes. Here, we explored these relationships using novel engineered mouse models carrying a deletion (Del/+) or a duplication (Dup/+) of the Sult1a1-Spn region homologous to the human 16p11.2 BP4-BP5...

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Identifiers

PMID: 26872257
DOI: 10.1371/journal.pgen.1005709
PMCID: PMC4752317

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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