Mouse population genetics phenocopies heterogeneity of human Chd8 haploinsufficiency.

Abstract excerpt

Preclinical models of neurodevelopmental disorders typically use single inbred mouse strains, which fail to capture the genetic diversity and symptom heterogeneity that is common clinically. We tested whether modeling genetic background diversity in mouse genetic reference panels would recapitulate population and individual differences in responses to a syndromic mutation in the high-confidence autism risk gene,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Behavior, Animal
• Share to Brain
• Share to DNA-Binding Proteins