Article
Heritability, correlations and in silico mapping of locomotor behavior and neurochemistry in inbred strains of mice.
Genes, brain, and behavior - 1 Jun 2005
Mhyre T R, Chesler E J, Thiruchelvam M, Lungu C, Cory-Slechta D A, Fry J D, Richfield E K
Abstract excerpt
The midbrain dopamine system mediates normal and pathologic behaviors related to motor activity, attention, motivation/reward and cognition. These are complex, quantitative traits whose variation among individuals is modulated by genetic, epigenetic and environmental factors. Conventional genetic methods have identified several genes important to this system, but the majority of factors contributing to the...
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