Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MDR1 gene polymorphism in Japanese patients with schizophrenia and mood disorders including depression.

Biological & pharmaceutical bulletin - 1 Dec 2006

Qian Wen, Homma Masato, Itagaki Fumio, Tachikawa Hirokazu, Kawanishi Yoichi, Mizukami Katsuyoshi, Asada Takashi, Inomata Shinichi, Honda Katsuya, Ohkohchi Nobuhiro, Kohda Yukinao

Abstract excerpt

P-Glycoprotein (ABCB1-type P-gp), a membrane protein encoded by the multi drug resistant gene (MDR1), expressing on the blood brain barrier protects the brain from many drugs including dexamethasone. Psychiatric disorders, schizophrenia and depression, have known to have abnormal hypothalamus-pituitary-adrenal (HPA) activity, which is assessed by non-suppression of cortisol in dexamethasone suppression test. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ATP Binding Cassette Transporter, Subfamily B, Member 1
Share to Depression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dexamethasone

Share to DNA Primers

Share to Introns

Share to Mood Disorders

Share to Schizophrenia

Source

Identifiers

PMID: 17142980
DOI: 10.1248/bpb.29.2446

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MDR1 gene polymorphism in Japanese patients with schizophrenia and mood disorders including depression.PMID 17142980Read ↗

Association between the functional polymorphism (C3435T) of the gene encoding P-glycoprotein (ABCB1) and major depressive disorder in the Japanese population.Semantic proximity Read ↗

Evaluation of the Role of ABCB1gene Polymorphic Variants on Psychiatric Disorders Predisposition in Macedonian Population.Semantic proximity Read ↗

Functional polymorphism of the human multidrug resistance gene (MDR1) and polydipsia-hyponatremia in schizophrenia.Semantic proximity Read ↗

Common genetic polymorphisms in the ABCB1 gene are associated with risk of major depressive disorder in male Portuguese individuals.Semantic proximity Read ↗

Association between multidrug resistance 1 (MDR1) gene polymorphisms and therapeutic response to bromperidol in schizophrenic patients: a preliminary study.Semantic proximity Read ↗

Association of dopamine transporter gene DAT1 40-bp 3' UTR VNTR polymorphism (rs28363170) with Psychiatric disorders susceptibility: A study from the Pakistani population.Semantic proximity Read ↗

The Influence of C3435T Polymorphism of the ABCB1 Gene on Genetic Susceptibility to Depression and Treatment Response in Polish Population - Preliminary Report.Semantic proximity Read ↗

Associations between MDR1 gene polymorphisms and schizophrenia and therapeutic response to olanzapine in female schizophrenic patients.Semantic proximity Read ↗

C3435T polymorphism of the MDR1 gene is not associated with blood levels of hypothalamus-pituitary-adrenal axis hormones in healthy male subjects.Semantic proximity Read ↗

Frequency of "Poor Transporter" Phenotype Among Patients with Mental Disorders: Pilot StudySemantic proximity Read ↗

ABCB1 C3435T polymorphism is associated with susceptibility to major depression, but not with a clinical response to citalopram in a Turkish population.Semantic proximity Read ↗

Distribution of allelic variants of functional C3435T polymorphism of drug transporter MDR1 gene in a sample of Polish population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.