Article
DSCAM promotes axon fasciculation and growth in the developing optic pathway.
Proceedings of the National Academy of Sciences of the United States of America - 14 Feb 2017
Bruce Freyja M, Brown Samantha, Smith Jonathan N, Fuerst Peter G, Erskine Lynda
Abstract excerpt
Although many aspects of optic pathway development are beginning to be understood, the mechanisms promoting the growth of retinal ganglion cell (RGC) axons toward visual targets remain largely unknown. Down syndrome cell adhesion molecule (Dscam) is expressed by mouse RGCs shortly after they differentiate at embryonic day 12 and is essential for multiple aspects of postnatal visual system development. Here we...
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