DSCAM promotes refinement in the mouse retina through cell death and restriction of exploring dendrites.

Abstract excerpt

In this study we develop and use a gain-of-function mouse allele of the Down syndrome cell adhesion molecule (Dscam) to complement loss-of-function models. We assay the role of Dscam in promoting cell death, spacing, and laminar targeting of neurons in the developing mouse retina. We find that ectopic or overexpression of Dscam is sufficient to drive cell death. Gain-of-function studies indicate that Dscam is not...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to bcl-2-Associated X Protein
• Share to Cell Adhesion Molecules