Article
Peripheral apoE isoform levels in cognitively normal APOE ε3/ε4 individuals are associated with regional gray matter volume and cerebral glucose metabolism.
Alzheimer's research & therapy - 30 Jan 2017
Nielsen Henrietta M, Chen Kewei, Lee Wendy, Chen Yinghua, Bauer Robert J, Reiman Eric, Caselli Richard, Bu Guojun
Abstract excerpt
BACKGROUND: Carriers of the APOE ε4 allele are at increased risk of developing Alzheimer's disease (AD), and have been shown to have reduced cerebral metabolic rate of glucose (CMRgl) in the same brain areas frequently affected in AD. These individuals also exhibit reduced plasma levels of apolipoprotein E (apoE) attributed to a specific decrease in the apoE4 isoform as determined by quantification of individual...
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