Article
KIR2DL4 genetic diversity in a Brazilian population sample: implications for transcription regulation and protein diversity in samples with different ancestry backgrounds.
Immunogenetics - 1 Jun 2021
Weiss Emiliana, Andrade Heloisa S, Lara Juliana Rodrigues, Souza Andreia S, Paz Michelle A, Lima Thálitta H A, Porto Iane O P, S B Silva Nayane, Castro Camila F Bannwart, Grotto Rejane M T, Donadi Eduardo A, Mendes-Junior Celso T, Castelli Erick C
Abstract excerpt
KIR2DL4 is an important immune modulator expressed in natural killer cells; HLA-G is its main ligand. We have characterized the KIR2DL4 genetic diversity by considering the promoter, all exons, and all introns in a highly admixed Brazilian population sample and by using massively parallel sequencing. We introduce a molecular method to amplify and to sequence the complete KIR2DL4 gene. To avoid the mapping bias...
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