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Cyclin-Dependent Kinase Inhibitor-1-Deficient Mice are Susceptible to Osteoarthritis Associated with Enhanced Inflammation.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 May 2017

Kihara Shinsuke, Hayashi Shinya, Hashimoto Shingo, Kanzaki Noriyuki, Takayama Koji, Matsumoto Tomoyuki, Chinzei Nobuaki, Iwasa Kenjiro, Haneda Masahiko, Takeuchi Kazuhiro, Nishida Kotaro, Kuroda Ryosuke

Abstract excerpt

Osteoarthritis (OA) is a multifactorial disease, and recent data suggested that cell cycle-related proteins play a role in OA pathology. Cyclin-dependent kinase (CDK) inhibitor 1 (p21) regulates activation of other CDKs, and recently, we reported that p21 deficiency induced susceptibility to OA induced by destabilization of the medial meniscus (DMM) surgery through STAT3-signaling activation. However, the...

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PMID: 28128866
DOI: 10.1002/jbmr.3080

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STAT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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