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Article

17-DMAG regulates p21 expression to induce chondrogenesis in vitro and in vivo

1 Oct 2018

Abstract excerpt

ABSTRACT Cartilage degeneration after injury affects a significant percentage of the population, including those that will go on to develop osteoarthritis (OA). Like humans, most mammals, including mice, are incapable of regenerating injured cartilage. Interestingly, it has previously been shown that p21 (Cdkn1a) knockout (p21−/−) mice demonstrate auricular (ear) cartilage regeneration. However, the loss of p21...

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PMID: 30305302
DOI: 10.1242/dmm.033662

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