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Article

Deletion of p21 expression accelerates cartilage tissue repair via chondrocyte proliferation.

Molecular medicine reports - 1 May 2020

Ibaraki Kazuyuki, Hayashi Shinya, Kanzaki Noriyuki, Hashimoto Shingo, Kihara Shinsuke, Haneda Masahiko, Takeuchi Kazuhiro, Niikura Takahiro, Kuroda Ryosuke

Abstract excerpt

Articular cartilage tissue has a poor healing potential, and when subjected to traumatic damage this tissue undergoes cartilage degeneration and osteoarthritis. The association between the regulation of cell cycle checkpoints and tissue regeneration has been previously investigated, and p21 was initially identified as a potent inhibitor of cell cycle progression. However, the effects of p21 defects on damaged...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32186772
DOI: 10.3892/mmr.2020.11028

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