Article

Susceptibility of Cyclin-dependent Kinase Inhibitor-1–deficient Mice to Rheumatoid Arthritis From IL-1β–induced Inflammation

2020-08-24

Abstract excerpt

<h4>Background: </h4> Rheumatoid arthritis (RA) is a chronic and systemic inflammatory disorder whose progression is modulated by fibroblast-like synoviocytes (FLSs). Cyclin-dependent kinase (CDK) inhibitor 1 (p21) regulates the activation of other CDKs, and we recently reported that p21 deficiency induces susceptibility to osteoarthritis. Here, we focused on joint inflammation to determine the mechanisms associat...

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Literature Corpus work: c1f6e5bf-a624-5f7f-958c-05be4cb060d2
DOI: 10.21203/rs.3.rs-62238/v1

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