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Article

Susceptibility of cyclin-dependent kinase inhibitor 1-deficient mice to rheumatoid arthritis arising from interleukin-1β-induced inflammation.

Scientific reports - 15 Jun 2021

Takashima Yoshinori, Hayashi Shinya, Fukuda Koji, Maeda Toshihisa, Tsubosaka Masanori, Kamenaga Tomoyuki, Kikuchi Kenichi, Fujita Masahiro, Kuroda Yuichi, Hashimoto Shingo, Nakano Naoki, Matsumoto Tomoyuki, Kuroda Ryosuke

Abstract excerpt

We recently reported that cyclin-dependent kinase inhibitor 1 (p21) deficiency induces osteoarthritis susceptibility. Here, we determined the mechanism underlying the effect of p21 in synovial and cartilage tissues in RA. The knee joints of p21-knockout (p21-/-) (n = 16) and wild type C57BL/6 (p21+/+) mice (n = 16) served as in vivo models of collagen antibody-induced arthritis (CAIA). Arthritis severity was...

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Identifiers

PMID: 34131243
DOI: 10.1038/s41598-021-92055-9
PMCID: PMC8206139

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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