Article
Human aldehyde dehydrogenases: potential pathological, pharmacological, and toxicological impact.
Journal of biochemical and molecular toxicology - 1 Jan 2003
Sládek Norman E
Abstract excerpt
Aldehyde dehydrogenases catalyze the pyridine nucleotide-dependent oxidation of aldehydes to acids. Seventeen enzymes are currently viewed as belonging to the human aldehyde dehydrogenase superfamily. Summarized herein, insofar as the information is available, are the structural composition, physical properties, tissue distribution, subcellular location, substrate specificity, and cofactor preference of each...
Topics
- Aldehyde Dehydrogenase
- Animals
- Humans
- Mutation
- Protein Subunits
- Signal Transduction
- Subcellular Fractions
- Substrate Specificity
- Tissue Distribution
