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Article

ZNF827 pleiotropic cardiovascular risk locus involves regulation by nuclear factor-1.

Clinical science (London, England : 1979) - 20 May 2026

Liu Yingwei, Liu Lu, Esmael Asraa, Tezza Alberto, London Charlie, Fustier Margaux-Alison, Georges Adrien, Bouatia-Naji Nabila

Abstract excerpt

Spontaneous coronary artery dissection (SCAD) is a form of myocardial infarction that predominantly affects middle-aged women, caused by the spontaneous onset of an intramural hematoma leading to heart ischemia. SCAD genetic risk loci, such as the ZNF827 locus on chromosome 4, were previously associated with the risk for coronary artery disease, systolic blood pressure, and ascending aortic diameter variability,...

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Topics

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Share to Fibroblasts
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

Share to Vascular Diseases

Source

Open in PubMed Open full text

Identifiers

PMID: 41983892
DOI: 10.1042/CS20257956
PMCID: PMC13161183

Genes

ZNF827
NF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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