Article
Coronary-Heart-Disease-Associated Genetic Variant at the COL4A1/COL4A2 Locus Affects COL4A1/COL4A2 Expression, Vascular Cell Survival, Atherosclerotic Plaque Stability and Risk of Myocardial Infarction.
PLoS genetics - 1 Jul 2016
Yang Wei, Ng Fu Liang, Chan Kenneth, Pu Xiangyuan, Poston Robin N, Ren Meixia, An Weiwei, Zhang Ruoxin, Wu Jingchun, Yan Shunying, Situ Haiteng, He Xinjie, Chen Yequn, Tan Xuerui, Xiao Qingzhong, Tucker Arthur T, Caulfield Mark J, Ye Shu
Abstract excerpt
Genome-wide association studies have revealed an association between coronary heart disease (CHD) and genetic variation on chromosome 13q34, with the lead single nucleotide polymorphism rs4773144 residing in the COL4A2 gene in this genomic region. We investigated the functional effects of this genetic variant. Analyses of primary cultures of vascular smooth muscle cells (SMCs) and endothelial cells (ECs) from...
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