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Article

Functional Characterization of Schizophrenia-Associated Variation in CACNA1C.

PloS one - 1 Jan 2016

Eckart Nicole, Song Qifeng, Yang Rebecca, Wang Ruihua, Zhu Heng, McCallion Andrew S, Avramopoulos Dimitrios

Abstract excerpt

Calcium channel subunits, including CACNA1C, have been associated with multiple psychiatric disorders. Specifically, genome wide association studies (GWAS) have repeatedly identified the single nucleotide polymorphism (SNP) rs1006737 in intron 3 of CACNA1C to be strongly associated with schizophrenia and bipolar disorder. Here, we show that rs1006737 marks a quantitative trait locus for CACNA1C transcript levels....

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Identifiers

PMID: 27276213
DOI: 10.1371/journal.pone.0157086
PMCID: PMC4898738

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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