Article
Genetic variants in CCNB1 associated with differential gene transcription and risk of coronary in-stent restenosis.
Circulation. Cardiovascular genetics - 1 Feb 2014
Silvestre-Roig Carlos, Fernández Patricia, Mansego María L, van Tiel Claudia M, Viana Rosa, Anselmi Chiara Viviani, Condorelli Gianluigi, de Winter Robbert J, Martín-Fuentes Paula, Solanas-Barca María, Civeira Fernando, Focaccio Amelia, de Vries Carlie J M, Chaves Felipe Javier, Andrés Vicente
Abstract excerpt
BACKGROUND: The development of diagnostic tools to assess restenosis risk after stent deployment may enable the intervention to be tailored to the individual patient, for example, by targeting the use of drug-eluting stent to high-risk patients, with the goal of improving safety and reducing costs. The CCNB1 gene (encoding cyclin B1) positively regulates cell proliferation, a key component of in-stent restenosis....
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