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Article

Functional Characterization of the GUCY1A3 Coronary Artery Disease Risk Locus.

Circulation - 1 Aug 2017

Kessler Thorsten, Wobst Jana, Wolf Bernhard, Eckhold Juliane, Vilne Baiba, Hollstein Ronja, von Ameln Simon, Dang Tan An, Sager Hendrik B, Moritz Rumpf Philipp, Aherrahrou Redouane, Kastrati Adnan, Björkegren Johan L M, Erdmann Jeanette, Lusis Aldons J, Civelek Mete, Kaiser Frank J, Schunkert Heribert

Abstract excerpt

BACKGROUND: A chromosomal locus at 4q32.1 has been genome-wide significantly associated with coronary artery disease risk. The locus encompasses GUCY1A3, which encodes the α1 subunit of the soluble guanylyl cyclase (sGC), a key enzyme in the nitric oxide/cGMP signaling pathway. The mechanism linking common variants in this region with coronary risk is not known. METHODS: Gene expression and protein expression...

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Identifiers

PMID: 28487391
DOI: 10.1161/CIRCULATIONAHA.116.024152
PMCID: PMC5560301

Genes

ZEB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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