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Article

TOMM40-APOE haplotypes are associated with cognitive decline in non-demented Blacks.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Aug 2021

Deters Kacie D, Mormino Elizabeth C, Yu Lei, Lutz Michael W, Bennett David A, Barnes Lisa L

Abstract excerpt

INTRODUCTION: The goal was to investigate effects of APOE-TOMM40-'523 haplotypes on cognitive decline in non-demented non-Hispanic Blacks (NHB), and determine whether effects differ from non-Hispanic Whites (NHW). METHODS: The impact of zero to two copies of the '523-Short variant (S; poly-T alleles < 20) within apolipoprotein E (APOE) genotype on a composite measure of global cognition and five domains was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33580752
DOI: 10.1002/alz.12295
PMCID: PMC8855738

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