Article
IRF4 rs12203592 functional variant and melanoma survival.
International journal of cancer - 15 Apr 2017
Potrony Miriam, Rebollo-Morell Aida, Giménez-Xavier Pol, Zimmer Lisa, Puig-Butille Joan Anton, Tell-Marti Gemma, Sucker Antje, Badenas Celia, Carrera Cristina, Malvehy Josep, Schadendorf Dirk, Puig Susana
Abstract excerpt
Inherited genetic factors may modulate clinical outcome in melanoma. Some low-to-medium risk genes in melanoma susceptibility play a role in melanoma outcome. Our aim was to assess the role of the functional IRF4 SNP rs12203592 in melanoma prognosis in two independent sets (Barcelona, N = 493 and Essen, N = 438). Genotype association analyses showed that the IRF4 rs12203592 T allele increased the risk of dying...
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