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Article

Association of inherited variation in Toll-like receptor genes with malignant melanoma susceptibility and survival.

PloS one - 1 Jan 2011

Gast Andreas, Bermejo Justo Lorenzo, Claus Rainer, Brandt Andreas, Weires Marianne, Weber Alexander, Plass Christoph, Sucker Antje, Hemminki Kari, Schadendorf Dirk, Kumar Rajiv

Abstract excerpt

The family of Toll-like receptors (TLRs) is critical in linking innate and acquired immunity. Polymorphisms in the genes encoding TLRs have been associated with autoimmune diseases and cancer. We investigated the genetic variation of TLR genes and its potential impact on melanoma susceptibility and patient survival. The study included 763 cutaneous melanoma cases recruited in Germany and 736 matched controls that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21931695
DOI: 10.1371/journal.pone.0024370
PMCID: PMC3170315

Genes

TLR4
TLR2
TLR3
TLR5

Provenance

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