Article
Inherited functional variants of the lymphocyte receptor CD5 influence melanoma survival.
International journal of cancer - 15 Sept 2016
Potrony Miriam, Carreras Esther, Aranda Fernando, Zimmer Lisa, Puig-Butille Joan-Anton, Tell-Martí Gemma, Armiger Noelia, Sucker Antje, Giménez-Xavier Pol, Martínez-Florensa Mario, Carrera Cristina, Malvehy Josep, Schadendorf Dirk, Puig Susana, Lozano Francisco
Abstract excerpt
Despite the recent progress in treatment options, malignant melanoma remains a deadly disease. Besides therapy, inherited factors might modulate clinical outcome, explaining in part widely varying survival rates. T-cell effector function regulators on antitumor immune responses could also influence survival. CD5, a T-cell receptor inhibitory molecule, contributes to the modulation of antimelanoma immune responses...
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