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Article

Genetic variants in PARP1 (rs3219090) and IRF4 (rs12203592) genes associated with melanoma susceptibility in a Spanish population.

BMC cancer - 27 Mar 2013

Peña-Chilet Maria, Blanquer-Maceiras Maite, Ibarrola-Villava Maider, Martinez-Cadenas Conrado, Martin-Gonzalez Manuel, Gomez-Fernandez Cristina, Mayor Matias, Aviles Juan Antonio, Lluch Ana, Ribas Gloria

Abstract excerpt

BACKGROUND: Few high penetrance genes are known in Malignant Melanoma (MM), however, the involvement of low-penetrance genes such as MC1R, OCA2, ASIP, SLC45A2 and TYR has been observed. Lately, genome-wide association studies (GWAS) have been the ideal strategy to identify new common, low-penetrance susceptibility loci. In this case-control study, we try to validate in our population nine melanoma associated...

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Source

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Identifiers

PMID: 23537197
DOI: 10.1186/1471-2407-13-160
PMCID: PMC3704782

Genes

PARP1
CCND1
ATM
ASIP
CASP8
NADSYN1
OCA2
TYR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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