Association of Interferon Regulatory Factor-4 Polymorphism rs12203592 With Divergent Melanoma Pathways.

doi:10.1093/jnci/djw004

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Article

Association of Interferon Regulatory Factor-4 Polymorphism rs12203592 With Divergent Melanoma Pathways.

Journal of the National Cancer Institute - 1 Jul 2016

Gibbs David C, Orlow Irene, Bramson Jennifer I, Kanetsky Peter A, Luo Li, Kricker Anne, Armstrong Bruce K, Anton-Culver Hoda, Gruber Stephen B, Marrett Loraine D, Gallagher Richard P, Zanetti Roberto, Rosso Stefano, Dwyer Terence, Sharma Ajay, La Pilla Emily, From Lynn, Busam Klaus J, Cust Anne E, Ollila David W, Begg Colin B, Berwick Marianne, Thomas Nancy E

Abstract excerpt

BACKGROUND: Solar elastosis and neval remnants are histologic markers characteristic of divergent melanoma pathways linked to differences in age at onset, host phenotype, and sun exposure. However, the association between these pathway markers and newly identified low-penetrance melanoma susceptibility loci remains unknown. METHODS: In the Genes, Environment and Melanoma (GEM) Study, 2103 Caucasian participants...

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PMID: 26857527
DOI: 10.1093/jnci/djw004
PMCID: PMC4948568

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