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Article

Genetic variation in IRF4 expression modulates growth characteristics, tyrosinase expression and interferon-gamma response in melanocytic cells.

Pigment cell & melanoma research - 1 Jan 2018

Chhabra Yash, Yong Hilary X L, Fane Mitchell E, Soogrim Arish, Lim Wen, Mahiuddin Dayana Nur, Kim Reuben S Q, Ashcroft Melinda, Beatson Scott A, Ainger Stephen A, Smit Darren J, Jagirdar Kasturee, Walker Graeme J, Sturm Richard A, Smith Aaron G

Abstract excerpt

A SNP within intron4 of the interferon regulatory factor4 (IRF4) gene, rs12203592*C/T, has been independently associated with pigmentation and age-specific effects on naevus count in European-derived populations. We have characterized the cis-regulatory activity of this intronic region and using human foreskin-derived melanoblast strains, we have explored the correlation between IRF4 rs12203592 homozygous C/C and...

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Source

Identifiers

PMID: 28755520
DOI: 10.1111/pcmr.12620

Genes

CTLA4
TYR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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