Article
Inherited Genetic Variants Associated with Melanoma BRAF/NRAS Subtypes.
The Journal of investigative dermatology - 1 Nov 2018
Thomas Nancy E, Edmiston Sharon N, Orlow Irene, Kanetsky Peter A, Luo Li, Gibbs David C, Parrish Eloise A, Hao Honglin, Busam Klaus J, Armstrong Bruce K, Kricker Anne, Cust Anne E, Anton-Culver Hoda, Gruber Stephen B, Gallagher Richard P, Zanetti Roberto, Rosso Stefano, Sacchetto Lidia, Dwyer Terence, Ollila David W, Begg Colin B, Berwick Marianne, Conway Kathleen
Abstract excerpt
BRAF and NRAS mutations arise early in melanoma development, but their associations with low-penetrance melanoma susceptibility loci remain unknown. In the Genes, Environment and Melanoma Study, 1,223 European-origin participants had their incident invasive primary melanomas screened for BRAF/NRAS mutations and germline DNA genotyped for 47 single-nucleotide polymorphisms identified as low-penetrant melanoma-risk...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.