Article
A landscape of synthetic viable interactions in cancer.
Briefings in bioinformatics - 20 Jul 2018
Gu Yunyan, Wang Ruiping, Han Yue, Zhou Wenbin, Zhao Zhangxiang, Chen Tingting, Zhang Yuanyuan, Peng Fuduan, Liang Haihai, Qi Lishuang, Zhao Wenyuan, Yang Da, Guo Zheng
Abstract excerpt
Synthetic viability, which is defined as the combination of gene alterations that can rescue the lethal effects of a single gene alteration, may represent a mechanism by which cancer cells resist targeted drugs. Approaches to detect synthetic viable (SV) interactions in cancer genome to investigate drug resistance are still scarce. Here, we present a computational method to detect synthetic viability-induced drug...
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