Synthetic viability induces resistance to immune checkpoint inhibitors in cancer cells

Abstract excerpt

Abstract Background Immune checkpoint inhibitors (ICI) have revolutionized the treatment for multiple cancers. However, most of patients encounter resistance. Synthetic viability (SV) between genes could induce resistance. In this study, we established SV signature to predict the efficacy of ICI treatment for melanoma. Methods We collected features and predicted SV gene pairs by random forest classifier. This...

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