Article

Gene expression has more power for predicting <i>in vitro</i> cancer cell vulnerabilities than genomics

2020-02-24

Abstract excerpt

Achieving precision oncology requires accurate identification of targetable cancer vulnerabilities in patients. Generally, genomic features are regarded as the state-of-the-art method for stratifying patients for targeted therapies. In this work, we conduct the first rigorous comparison of DNA- and expression-based predictive models for viability across five datasets encompassing chemical and genetic perturbations...

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Literature Corpus work: 7c9ad32f-3a07-5ae6-9103-4a520e7a5a1c
DOI: 10.1101/2020.02.21.959627

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