Article

Genome-wide prediction of synthetic rescue mediators of resistance to targeted and immunotherapy

2018-03-18

Abstract excerpt

<h4>ABSTRACT</h4> Most patients with advanced cancer eventually acquire resistance to targeted therapies, spurring extensive efforts to identify molecular events mediating therapy resistance. Many of these events involve synthetic rescue (SR) interac tions, where the reduction in cancer cell viability caused by targeted gene inactivation is rescued by an adaptive alteration of another gene (the rescuer ). Here...

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Literature Corpus work: 76d78359-26f4-52a1-8523-9c8bd6ddb0e7
DOI: 10.1101/284240

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