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Article

Conformational dynamics and self-association of intrinsically disordered Huntingtin exon 1 in cells.

Physical chemistry chemical physics : PCCP - 3 May 2017

Büning Steffen, Sharma Abhishek, Vachharajani Shivang, Newcombe Estella, Ormsby Angelique, Gao Mimi, Gnutt David, Vöpel Tobias, Hatters Danny M, Ebbinghaus Simon

Abstract excerpt

Huntington's disease is caused by a CAG trinucleotide expansion mutation in the Huntingtin gene that leads to an artificially long polyglutamine sequence in the Huntingtin protein. A key feature of the disease is the intracellular aggregation of the Huntingtin exon 1 protein (Httex1) into micrometer sized inclusion bodies. The aggregation process of Httex1 has been extensively studied in vitro, however, the...

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Identifiers

PMID: 28094373
DOI: 10.1039/c6cp08167c

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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