Article
Formation and Structure of Wild Type Huntingtin Exon-1 Fibrils.
Biochemistry - 18 Jul 2017
Isas J Mario, Langen Andreas, Isas Myles C, Pandey Nitin K, Siemer Ansgar B
Abstract excerpt
The fact that the heritable neurodegenerative disorder Huntington's disease (HD) is autosomal dominant means that there is one wild type and one mutant allele in most HD patients. The CAG repeat expansion in the exon 1 of the protein huntingtin (HTTex1) that causes the disease leads to the formation of HTT fibrils in vitro and vivo. An important question for understanding the molecular mechanism of HD is which...
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