Huntingtin Inclusions Trigger Cellular Quiescence, Deactivate Apoptosis, and Lead to Delayed Necrosis.

doi:10.1016/j.celrep.2017.04.029

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Article

Huntingtin Inclusions Trigger Cellular Quiescence, Deactivate Apoptosis, and Lead to Delayed Necrosis.

Cell reports - 2 May 2017

Ramdzan Yasmin M, Trubetskov Mikhail M, Ormsby Angelique R, Newcombe Estella A, Sui Xiaojing, Tobin Mark J, Bongiovanni Marie N, Gras Sally L, Dewson Grant, Miller Jason M L, Finkbeiner Steven, Moily Nagaraj S, Niclis Jonathan, Parish Clare L, Purcell Anthony W, Baker Michael J, Wilce Jacqueline A, Waris Saboora, Stojanovski Diana, Böcking Till, Ang Ching-Seng, Ascher David B, Reid Gavin E, Hatters Danny M

Abstract excerpt

Competing models exist in the literature for the relationship between mutant Huntingtin exon 1 (Httex1) inclusion formation and toxicity. In one, inclusions are adaptive by sequestering the proteotoxicity of soluble Httex1. In the other, inclusions compromise cellular activity as a result of proteome co-aggregation. Using a biosensor of Httex1 conformation in mammalian cell models, we discovered a mechanism that...

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PMID: 28467905
DOI: 10.1016/j.celrep.2017.04.029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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