Article
Genomic analysis of globally diverse Mycobacterium tuberculosis strains provides insights into the emergence and spread of multidrug resistance.
Nature genetics - 1 Mar 2017
Manson Abigail L, Cohen Keira A, Abeel Thomas, Desjardins Christopher A, Armstrong Derek T, Barry Clifton E, Brand Jeannette, Chapman Sinéad B, Cho Sang-Nae, Gabrielian Andrei, Gomez James, Jodals Andreea M, Joloba Moses, Jureen Pontus, Lee Jong Seok, Malinga Lesibana, Maiga Mamoudou, Nordenberg Dale, Noroc Ecaterina, Romancenco Elena, Salazar Alex, Ssengooba Willy, Velayati A A, Winglee Kathryn, Zalutskaya Aksana, Via Laura E, Cassell Gail H, Dorman Susan E, Ellner Jerrold, Farnia Parissa, Galagan James E, Rosenthal Alex, Crudu Valeriu, Homorodean Daniela, Hsueh Po-Ren, Narayanan Sujatha, Pym Alexander S, Skrahina Alena, Swaminathan Soumya, Van der Walt Martie, Alland David, Bishai William R, Cohen Ted, Hoffner Sven, Birren Bruce W, Earl Ashlee M
Abstract excerpt
Multidrug-resistant tuberculosis (MDR-TB), caused by drug-resistant strains of Mycobacterium tuberculosis, is an increasingly serious problem worldwide. Here we examined a data set of whole-genome sequences from 5,310 M. tuberculosis isolates from five continents. Despite the great diversity of these isolates with respect to geographical point of isolation, genetic background and drug resistance, the patterns for...
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