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Cryptic Resistance Mutations Associated With Misdiagnoses of Multidrug-Resistant Tuberculosis

11 Mar 2019

Abstract excerpt

Understanding why some multidrug-resistant tuberculosis cases are not detected by rapid phenotypic and genotypic routine clinical tests is essential to improve diagnostic assays and advance toward personalized tuberculosis treatment. Here, we combine whole-genome sequencing with single-colony phenotyping to identify a multidrug-resistant strain that had infected a patient for 9 years. Our investigation revealed...

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PMID: 30875421
DOI: 10.1093/infdis/jiz104

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