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Genetic Characterization of First-Line Drug-Resistance Mutations in Multidrug-Resistant Mycobacterium tuberculosis.

Pathogens (Basel, Switzerland) - 22 Apr 2026

Gul Maryam, Ali Sajid, Rehman Abdul, Qasim Muhammad, Ali Roomana, Phelan Jody E, Waheed Aiman, Ahmad Sajjad, Hussain Mubbashir, Campino Susana, Clark Taane G, Khan Taj Ali

Abstract excerpt

BACKGROUND: Resistance to first-line anti-tuberculosis drugs in Mycobacterium tuberculosis represents a significant public health challenge, particularly in high-burden tuberculosis (TB) settings such as Pakistan, where multidrug-resistant (MDR) forms further complicate disease control efforts. Drug resistance is primarily associated with mutations in rpoB, inhA, katG, embA, embB, embC, and pncA. The emergence of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 42198582
DOI: 10.3390/pathogens15050455
PMCID: PMC13209609

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