Article
Uncovering resistance pathways to first- and last-line antibiotics in Mycobacterium tuberculosis populations.
Microbial genomics - 1 May 2026
Srilohasin Prapaporn, Williams Jasmine M, Tay Aidan P, Gillieatt Brodie F, Pascoe Daniel R, Maharjan Ram P, Chaipraset Angkana, Ajawatanawong Pravech, Cain Amy K
Abstract excerpt
Tuberculosis (TB), caused by Mycobacterium tuberculosis, is one of the world's deadliest diseases, currently responsible for ~1.5 million deaths per year and rising. Recently, rifampicin-resistant M. tuberculosis was designated as a critical priority pathogen status by the World Health Organization. However, few controlled laboratory studies are available that systematically assess the molecular drivers of...
Topics
- Mycobacterium tuberculosis
- Rifampin
- Linezolid
- Mutation
- Drug Resistance, Bacterial
- Humans
- Antitubercular Agents
- Bacterial Proteins
- Microbial Sensitivity Tests
- Directed Molecular Evolution