Genomic-based surveillance reveals high ongoing transmission of multi-drug-resistant Mycobacterium tuberculosis in Southern Brazil.

doi:10.1016/j.ijantimicag.2021.106401

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Genomic-based surveillance reveals high ongoing transmission of multi-drug-resistant Mycobacterium tuberculosis in Southern Brazil.

International journal of antimicrobial agents - 1 Oct 2021

Salvato Richard Steiner, Reis Ana Júlia, Schiefelbein Sun Hee, Gómez Michael Andrés Abril, Salvato Stéphanie Steiner, da Silva Larissa Vitória, Costa Elis Regina Dalla, Unis Gisela, Dias Claudia Fontoura, Viveiros Miguel, Portugal Isabel, von Groll Andrea, da Silva Pedro Eduardo Almeida, Kritski Afrânio Lineu, Perdigão João, Rossetti Maria Lucia Rosa

Abstract excerpt

Genomic-based surveillance on the occurrence of drug resistance and its transmission dynamics has emerged as a powerful tool for the control of tuberculosis (TB). A whole-genome sequencing approach, phenotypic testing and clinical-epidemiological investigation were used to undertake a retrospective population-based study on drug-resistant (DR)-TB in Rio Grande do Sul, the largest state in Southern Brazil. The...

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PMID: 34289403
DOI: 10.1016/j.ijantimicag.2021.106401

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