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Whole-genome sequencing of clinical isolates from tuberculosis patients in India: real-world data indicates a high proportion of pre-XDR cases.

Microbiology spectrum - 2 May 2024

Bhanushali Aparna, Atre Sachin, Nair Preethi, Thandaseery Geethanjali Anilkumar, Shah Sanchi, Kuruwa Sanjana, Zade Amrutraj, Nikam Chaitali, Gomare Mangala, Chatterjee Anirvan

Abstract excerpt

Treatment decisions for tuberculosis (TB) in the absence of full drug-susceptibility data can result in amplifying resistance and may compromise treatment outcomes. Genomics of Mycobacterium tuberculosis (M.tb) from clinical samples enables detection of drug resistance to multiple drugs. We performed whole-genome sequencing (WGS) for 600 clinical samples from patients with tuberculosis to identify the...

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Identifiers

PMID: 38597637
DOI: 10.1128/spectrum.02770-23
PMCID: PMC11064594

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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