Article
A lipid-regulated docking site on vinculin for protein kinase C.
The Journal of biological chemistry - 1 Mar 2002
Ziegler Wolfgang H, Tigges Ulrich, Zieseniss Anke, Jockusch Brigitte M
Abstract excerpt
During cell spreading, binding of actin-organizing proteins to acidic phospholipids and phosphorylation are important for localization and activity of these proteins at nascent cell-matrix adhesion sites. Here, we report on a transient interaction between the lipid-dependent protein kinase Calpha and vinculin, an early component of these sites, during spreading of HeLa cells on collagen. In vitro binding of...
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