Effects of low-level ciprofloxacin challenge in the in vitro development of ciprofloxacin resistance in Campylobacter jejuni.

doi:10.1089/mdr.2008.0833

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Article

Effects of low-level ciprofloxacin challenge in the in vitro development of ciprofloxacin resistance in Campylobacter jejuni.

Microbial drug resistance (Larchmont, N.Y.) - 1 Sept 2008

Hannula Minna, Hänninen Marja-Liisa

Abstract excerpt

The effects on MIC values and the selection of different base substitutions in the quinolone resistance determining region (QRDR) of gyrA were studied on initially ciprofloxacin-susceptible Campylobacter jejuni strains by challenging them to 0.125 mg/L of ciprofloxacin. This ciprofloxacin challenge selected variants with ciprofloxacin MIC levels up to 32 mg/L. Repeated experiments under identical conditions...

Topics

Animals
Anti-Infective Agents
Base Sequence
Campylobacter jejuni
Chickens
Ciprofloxacin
DNA Gyrase
DNA Mutational Analysis
DNA, Bacterial
Dose-Response Relationship, Drug
Drug Resistance, Bacterial
Microbial Sensitivity Tests
Mutation

Source

Open in PubMed

Identifiers

PMID: 18713066
DOI: 10.1089/mdr.2008.0833

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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