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Article

Population Bottlenecks Strongly Influence the Evolutionary Trajectory to Fluoroquinolone Resistance in Escherichia coli.

Molecular biology and evolution - 1 Jun 2020

Garoff Linnéa, Pietsch Franziska, Huseby Douglas L, Lilja Tua, Brandis Gerrit, Hughes Diarmaid

Abstract excerpt

Experimental evolution is a powerful tool to study genetic trajectories to antibiotic resistance under selection. A confounding factor is that outcomes may be heavily influenced by the choice of experimental parameters. For practical purposes (minimizing culture volumes), most experimental evolution studies with bacteria use transmission bottleneck sizes of 5 × 106 cfu. We currently have a poor understanding of...

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Identifiers

PMID: 32031639
DOI: 10.1093/molbev/msaa032
PMCID: PMC7253196

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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