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Article

Dominant resistance and negative epistasis can limit the co-selection of de novo resistance mutations and antibiotic resistance genes.

Nature communications - 5 Mar 2020

Porse Andreas, Jahn Leonie J, Ellabaan Mostafa M H, Sommer Morten O A

Abstract excerpt

To tackle the global antibiotic resistance crisis, antibiotic resistance acquired either vertically by chromosomal mutations or horizontally through antibiotic resistance genes (ARGs) have been studied. Yet, little is known about the interactions between the two, which may impact the evolution of antibiotic resistance. Here, we develop a multiplexed barcoded approach to assess the fitness of 144 mutant-ARG...

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Share to Aminoglycosides
Share to Base Sequence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Membrane Permeability

Share to Drug Resistance, Microbial

Share to Epistasis, Genetic

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Share to Membrane Transport Proteins

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Source

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Identifiers

PMID: 32139686
DOI: 10.1038/s41467-020-15080-8
PMCID: PMC7057998

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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